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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

Jan 29, 2009

This audio program discusses factors related to the emergence of mania during antidepressant treatment for bipolar depression; manic symptoms observed during bipolar depression among STEP-BD participants; the attitude of older adults toward enrollment of noncompetent subjects in Alzheimer’s disease research; the association between cerebral deficits and clinical symptoms in antipsychotic-naive, first-episode schizophrenia patients; whether altered amygdala activity in schizophrenia is related to clinical state or to genetic risk; brain structure in schizophrenia patients with relatively intact cognitive functioning; and an odor-detection sensitivity deficit in patients with schizophrenia and its implications for cyclic AMP signaling. Articles can be viewed online at