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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

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  2. February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial

February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial

Feb 1, 2026

Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

  • 00:53   Doxycycline and the risk of developing schizophrenia
  • 04:03   Emulated target trials versus randomized control trials
  • 06:43   Methods of action
  • 09:24   Dosage and exposure levels for doxycycline
  • 10:15   Immediate clinical applications
  • 10:56   Limitations of the study
  • 11:33   Future research
  • 12:43   Kalin interview
  • 13:00   Lång et al.
  • 19:43   Zhao et al.
  • 25:20   Metrik et al.

Transcript

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