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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

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  2. June 2026: Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

June 2026: Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

Jun 1, 2026

Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of ketamine treatment in patients with major depressive disorder and suicidal ideation.  AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the June issue of the Journal, which takes a close look at issues surrounding suicide and severe depression.

  • 01:20     Tucciarone and Schatzberg interview
  • 03:36     Disparity between effects on suicidal ideation and antidepressant ratings
  • 05:36     Ethics of placebo and ketamine in patients with suicidal ideation
  • 08:28     Immediate clinical implications
  • 11:40     Limitations
  • 14:10     Further research
  • 16:19     Kalin interview
  • 16:24     Tucciarone et al.
  • 20:39     Rovers et al.
  • 24:30     Jelen et al.

Transcript

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