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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

Mar 1, 2023

Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue.


  • Sachs interview [00:47]
  • Why is treating major depressive disorder in patients proven to be such a challenge for clinicians? [01:54]
  • Why cariprazine in conjunction with antidepressants? [02:37]
  • Atypical antipsychotics and antidepressants [03:22]
  • Atypical antipsychotics and side effects [05:23]
  • Limitations [07:09]
  • Clinical implications for the treatment of major depressive disorder [08:29]
  • What’s next for your research? [09:15]
  • Kalin interview [10:09]
  • Sachs et al. [10:25]
  • Hasseris et al. [12:35]
  • Visontay et al. [15:15]
  • Dunlop et al. [17:10]
  • Elbau et al. [19:56]

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