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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

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  2. March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials

March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials

Mar 1, 2025

Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

  • 00:45     Horan interview
  • 03:15     Novel mechanism of action in the treatment of schizophrenia
  • 05:39     Side effect profiles
  • 07:20     Clinical impacts
  • 08:31     The need for further investigation
  • 09:58     Limitations
  • 11:05     Further research
  • 13:08     Kalin interview
  • 13:21     Horan et al.
  • 17:34     Levenstein et al.
  • 19:00     Fountoulakis et al.
  • 20:57     Couture et al.
  • 23:18     Stern et al.
  • 27:35     McGirr et al.

Transcript

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