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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

May 1, 2020

Executive Editor Michael Roy speaks with Collin Reiff, M.D., and William McDonald, M.D., about their evidence-based summary of the literature on the clinical application of psychedelic drugs in psychiatric disorders.

  • How hallucinogens were first used, and some of the key individuals involved in the development of these drugs for medical use [2:23]
  • What led to the worry about use of these compounds in the 1960s, and what actions did U.S. policymakers take at the time? [5:35]
  • How have opinions changed from the 1960s to the present? [7:01]
  • How the authors conducted their research [8:23]
  • How the authors determined which drugs to examine [9:38]
  • What findings stood out to the authors? [10:28]
  • Relationships between the psychological effects and the neurobiology of psychedelic compounds [12:59]
  • How ketamine came to be used in clinical care, and what studies have shown about its safety and effectiveness [14:18]
  • An outline of psycholytic therapy and psychedelic therapy [17:16]
  • What is the potential for these kinds of drugs to be misused? [19:24]
  • Conclusions that researchers, clinicians, and other mental health professionals should take away [21:15]
  • Recommendations for further research in this area [22:20]

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