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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

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  2. November 2022: Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

November 2022: Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

Nov 1, 2022

Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together.

  • Seligowski interview [00:50]
  • Genome-wide association studies [02:24]
  • The Mass General Brigham Biobank [03:05]
  • What were the limitations of the study? [04:05]
  • Are there current clinical implications? [05:04]
  • How does depression fit in? [06:11]
  • Are the links between PTSD and cardiovascular disease linked to associated comorbidities? [07:00]
  • What’s next for your research? [07:52]
  • Kalin interview [08:51]
  • Seligowski et al. [09:06]
  • Leone et al. [10:57]
  • Hindley et al. [13:50]
  • Lewis and Vassos [17:37]
  • Sigström et al. [18:13]
  • Brownstein et al. [20:32]
  • In summary [25:03]

Transcript

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